CHK2 INHIBITOR II

Product Name: CHK2 INHIBITOR II
CAS No.: 516480-79-8
Chemical Name: CHK2 INHIBITOR II
Synonyms: C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;BML-277 (C 3742);C 3742 BML-277;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II hydrate;Chk2 Inhibitor II (BML-277)
CBNumber: CB9503256
Molecular Formula: C20H14ClN3O2
Formula Weight: 363.8
MOL File: 516480-79-8.mol

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CHK2 INHIBITOR II Property

Boiling point:: 637.1±63.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 18 mg/mL
form: solid
pka: 10.40±0.10(Predicted)
color: tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 220486
Product name: Chk2 Inhibitor II
Packaging: 1mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 220491
Product name: InSolution? Chk2 Inhibitor II
Packaging: 5mg
Price: $280
Updated: 2023/01/07

Cayman Chemical

Product number: 17552
Product name: Chk2 Inhibitor II
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17552
Product name: Chk2 Inhibitor II
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Sigma-Aldrich

Product number: C3742
Product name: Chk2 Inhibitor II hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $220
Updated: 2024/03/01

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CHK2 INHIBITOR II Chemical Properties,Usage,Production

Description

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC₅₀ = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.

Uses

Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

Biochem/physiol Actions

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).

References

1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873 2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819

CHK2 INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CHK2 INHIBITOR II Suppliers

China 75 France 1 India 1 Switzerland 1 United Kingdom 1 United States 17 Global 96

MedChemexpress LLC

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InvivoChem

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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
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ProdList: 2738
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BOC Sciences

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Aladdin Scientific

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View Lastest Price from CHK2 INHIBITOR II manufacturers

Career Henan Chemical Co

Product: CHK2 INHIBITOR II 516480-79-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

516480-79-8, CHK2 INHIBITOR IIRelated Search:

DMOG 5-Fluorouracil 8-OXO-2'-DEOXYGUANOSINE 3-Aminobenzamide Debromo Hymenialdisine

2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, >98%

BML-277, >98%

BML-277 (C 3742)

CS-1761

BML-277,CHK2 INHIBITOR II

CHK2 INHIBITOR II; C 3742; BML277; BML 277

Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide

C 3742

BML-277

2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE

2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide

C 3742 BML-277

InSolution? Chk2 Inhibitor II

2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide

2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate

Chk2 Inhibitor II hydrate

Chk2 Inhibitor II (BML-277)

1H-Benzimidazole-6-carboxamide, 2-[4-(4-chlorophenoxy)phenyl]-

2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide

inhibit,Checkpoint Kinase (Chk),Inhibitor,BML277,BML-277,Apoptosis

Chk2InhibitorⅡ

516480-79-8

Inhibitors

API